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There was no encounter to date with the use of METROGEL-VAGINAL in pregnant individuals. Metronidazole crosses the placental barrier and enters the fetal circulation promptly. No fetotoxicity or teratogenicity was observed when metronidazole was administered orally to pregnant mice at 6 occasions the advisable human dose (dependant on mg/m2); nonetheless, in one smaller analyze wherever the drug was administered intraperitoneally, some intrauterine deaths were being observed. The connection of those conclusions towards the drug is unidentified.
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Use of cimetidine with oral metronidazole might lengthen the fifty percent-lifestyle and reduce plasma clearance of metronidazole.
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The looks of abnormal neurologic indicators calls for the prompt discontinuation of metronidazole vaginal gel therapy. Metronidazole vaginal gel really should be administered with caution to people with central nervous system diseases.
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Usually do not acquire goods that contains Liquor or propylene glycol though utilizing this medication and for at least 24 hours soon after halting this medication. Check with your pharmacist for more specifics.
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